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Creating the next generation of cancer treatments
Pipeline


PIPELINE


Arno has exclusive worldwide rights to develop and market three innovative pre-clinical and clinical-stage product candidates with unique mechanisms of action. These compounds have the potential to be first-in-class products for the treatment of hematologic malignancies and solid tumors.

Product Pipeline


Onapristone


Drug Description

Onapristone is a progesterone receptor antagonist that has demonstrated anti-tumor activity in preclinical and clinical studies of hormone-dependent tumors. Its mechanism of action is thought to be a direct result of binding to the progesterone receptor and preventing the progesterone receptor from binding to DNA, thereby substantially reducing or eliminating progesterone-receptor-induced transcription resulting in death or differentiation of the malignant cells.

Development History

Onapristone was originally developed by Schering AG. Early stage clinical studies conducted in Europe in post-menopausal women with breast cancer showed encouraging anti-tumor activity but also transient elevated liver function test. Arno Therapeutics is conducting additional research to potentially identify patients who would benefit most from onapristone and has entered into a licensing agreement with Invivis Pharmaceuticals in 2012 for further development.

Clinical Findings

Onapristone has been evaluated in clinical studies as both first- and second-line treatment for primary and metastatic breast cancer. In clinical studies, onapristone has demonstrated a 56% objective response rate as a first-line endocrine treatment of breast cancer and a 49% clinical benefit rate in patients with breast cancer previously treated wiht tamoxifen. Future studies of onapristone may be conducted in combination with other endocrine agents to improve previous results observed in patients with breast cancer.

Current Development Plan

Arno plans to develop this compound for the treatment of a variety of tumor types, including breast and endometrial cancer. The company is preparing to conduct preclinical toxicology studies and has begun work on a predictive diagnostic biomarker to determine which patients would benefit most from onapristone treatment. Following completion of preclinical studies and initiation of the development of a companion diagnostic, we intend to file an IND with the FDA to begin a dose-escalation Phase I study of onapristone in patients with endometrial and breast cancer.

Select Bibliography

  • J.F.R. Robertson et al., Onapristone, a Progesterone Receptor Antagonist, as First-Line Therapy in Primary Breast Cancer, European Journal of Cancer, Vol. 35, No. 2, pp. 214-218, 1999.
  • J.G.M. Klijn et al., Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer, Steroids, v. 65, pp. 825-830, 2000.
  • W. Jonatt et al., The clinical efficacy of progesterone antagonists in breast cancer, in Endocrine Therapy of Breast Cancer, pp. 117-124.



AR-42


Drug Description

AR-42 is a novel, oral agent therapy currently in early clinical development. It is a broad-spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies when compared in preclinical studies to vorinostat (also known as "SAHA" or Zolinza®), the first of two marketed compounds in the class. AR-42 may possess additional histone-independent mechanisms, which may contribute to its superior profile in vitro and in vivo. It has been designated an orphan drug by the FDA for the treatment of meningioma and schwannoma of the central nervous system. Meningioma and schwannoma are rare, benign tumors that can present in different locations within the brain and the spinal cord and may cause substantial morbidity.

Development History

AR-42 was licensed to Arno in January 2008 by The Ohio State University Research Foundation for commercial development by Arno.

Preclinical Findings

In preclinical models, AR-42 has shown to be more potent or effective than SAHA in various cancer types, including chronic lymphocyte leukemia, or CLL, B-cell lymphoma, prostate and ovarian cancers. Preclinical studies suggest that AR-42 has anti-cancer activities that are independent of histone acetylation and which disrupt the growth and proliferation of cancer cells. We believe that this combination of activity and potency could make AR-42 a more effective treatment for hematological malignancies than currently available HDAC inhibitors and a potential treatment of a number of solid tumors. In addition, pre-clinical models have demonstrated anti-tumor activity in tumor types (schwannoma and meningioma) that are associated with the genetic illness neurofibromatosis type 2. Additional pre-clinical data presented at the 2009 American Society of Hematology Annual Meeting showed that AR-42 potently and selectively inhibits leukemic stem cells in acute myeloid leukemia.

Development Plan

AR-42 is currently in an investigator-initiated dose-ranging Phase I/IIa clinical trial for treatment of relapsed or recurrent hematological malignancies and solid tumors for which standard treatment has failed or not proven to be effective. The ongoing study is designed so that additional patients with hematological malignancies can be added to investigate the potential efficacy of AR-42 in a particular disease and help guide future Phase II programs once the recommended dose for further study has been defined. During 2012, we intend to collaborate with The Ohio State University to conduct an investigator-initiated study of AR-42 in patients with schwannoma and meningioma to assess intra-tumoral concentrations of AR-42, identify apoptosis markers and assess gene regulation.

CLINICAL PROGRAM
For information about the current clinical program, please Click Here




AR-12


Drug Description

AR-12 is a potentially first-in-class, orally available, targeted anti-cancer agent that has been shown in preclinical studies to inhibit phosphoinositide-dependent protein kinase-1, or PDK-1, a protein in the PI3K/Akt pathway that is involved in the growth and proliferation of cells, including cancer cells. Although FDA-approved drugs that target the Akt pathway have shown efficacy in treating cancer, some tumors either do not respond to these drugs or eventually become resistant to therapy. Scientists hypothesize that a combination of drugs that inhibit different targets in this pathway could provide synergistic or additive benefits to increase efficacy and potentially overcome drug resistance. For this reason, there has been particular interest within the biopharmaceutical industry in developing inhibitors of PI3K, PDK-1, and Akt.

Development History

AR-12 was licensed to Arno in January 2008 by The Ohio State University Research Foundation for commercial development by Arno as a potential treatment for solid tumors and hematological malignancies.

Preclinical Findings

In preclinical studies, AR-12 has shown efficacy in a wide range of tumor types, including breast, lung, prostate, pancreatic, brain and hematological cancers, as both a single-agent as well as in combination with leading oncology therapeutics. AR-12 demonstrated synergy or additive benefit or overcame drug-resistance when used in combination with Avastin®, Herceptin®, Gleevec®, Tarceva®, Iressa®, Nexavar® and tamoxifen, all of which are widely prescribed, FDA-approved oncology therapeutics that, according to Thomson Reuters Pharma, represented approximately $17 billion in sales in 2009.

Development Plan

We are currently conducting a multi-centered, two-part, Phase I clinical study of AR-12 in adult patients with advanced or recurrent solid tumors or lymphoma. The first part is a dose-escalating study to evaluate the safety of AR-12 and identify the maximum tolerated dose and recommended Phase II dose for future studies. The second part of the study was to be a cohort expansion at the recommended phase 2 dose in selected "tumor types". We will not be proceeding with the second part of the study, as we plan to develop a revised formulation of AR-12 with greater bioavailability which will require a new Phase I study to be performed.

Select Bibliography

  • Tseng PH et al., Mol. Pharmacol. 2006 Nov; 70(5):1534-41
  • Cen L et al., British J. Cancer (2007) 97, 785-791
  • Ping-Hui Tseng et al., Blood (2005) 105: 4021-4027
CLINICAL PROGRAM
For information about the current clinical program, please go to Click Here



Arno Therapeutics, Inc.
200 Route 31 North
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